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Celiac Disease Is Not The Only Allergy Associated With Wheat Consumption

November 5, 2013: 12:00 AM EST
Not all allergic reactions to wheat are caused by celiac disease, according to Italian researchers who studied data on 276 patients diagnosed with a unique disorder known as non-celiac wheat sensitivity (NCWS). In a double-blind, placebo-controlled wheat challenge, the researchers found that NCWS patients may be suffering from a non-lgE mediated food allergy, like celiac disease, that primarily affects the innermost layer of the GI tract. Symptoms are delayed, making it difficult to diagnose. NCWS symptoms involve the gastrointestinal tract, the nervous system, the skin and other organs. Symptoms disappear when wheat is excluded from the diet, and come back when  wheat consumption resumes.
Antonio Carroccio et al., "Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review", The American Journal of Gastroenterology, November 05, 2013, © The American College of Gastroenterology
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