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Fasting, Rather Than Frequent Snacking, Can Lead To Weight Gain

June 5, 2015: 12:00 AM EST
A U.S. study in mice finds that limiting eating to one large meal a day, compared to eating several small meals, is more likely to lead to insulin resistance in the liver, prediabetes, and weight gain. The liver doesn’t respond to insulin signals telling it to stop producing glucose; the excess blood glucose tends to be stored in the abdomen as fat. That stored visceral fat increases the risk of type 2 diabetes and heart disease. The findings suggest that human dieters should not skip meals to save calories because that causes large fluctuations in insulin and glucose. That in turn results in weight gain, rather than weight loss.
Kara L. Kliewer et al., "Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. ", The Journal of Nutritional Biochemistry, June 05, 2015, © Elsevier Inc.
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