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Measuring Two Appetite Hormones Before Dieting Predicts Whether Weight Will Be Regained

June 25, 2012: 12:00 AM EST
Scientists in Spain have determined that measuring the levels of two hormones before a dieting program is begun can accurately predict whether dieters will regain lost weight. The two hormones – leptin and ghrelin – help regulate the appetite. The researchers found the pre-diet leptin/ghrelin ratio to be two times higher among study participants who later regained weight than among those who did not. They also identified cut-off points that predicted more than 60 percent of patients who would later regain 10 percent or more of the weight they initially lost. Calculating the leptin/ghrelin ratio might help in personalizing weight-loss programs for more effective control of obesity, the researchers said.
Ana B. Crujeiras, "Ratio of Appetite Regulating Hormones Marker of Successful Dieters", News release, presentation at The Endocrine Society annual meeting, June 25, 2012, © Endocrine Society
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