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Report Suggests Fructose Metabolism May Increase Food Intake, Obesity

March 2, 2009: 01:36 AM EST
In a review of prior studies, researchers at The Johns Hopkins University School of Medicine determined a link between the consumption of fructose and increased food intake, which may contribute to a high incidence of obesity, and Type 2 diabetes. In the brain, malonyl-CoA has a critical role in monitoring energy balance gauged through glucose levels. But the researchers find fructose has the opposite effect of glucose on the malonyl-CoA signaling system, effectively encouraging food intake. The researchers argue that the fact that fructose metabolism by the brain increases food intake and obesity risk raises health concerns about high fructose sweeteners, especially by youth.
Daniel Lane et al, "Effect Of Glucose And Fructose On Food Intake Via Malonyl-Coa Signaling In The Brain.", Biochemical and Biophysical Research Communications, March 02, 2009, © Elsevier
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