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Signals From Fat May Be Telling Body Cells To Ignore Appetite Suppressors

September 14, 2009: 08:55 AM EST
Researchers at The University of Texas Southwestern Medical Center have found in a rat study that fat, notably the saturated fat palmitic acid in dairy products and beef, may send messages to the body’s cells telling them to ignore the normal appetite-suppressant signals of leptin and insulin. The scientists believe saturated fat actually lowers the body’s own natural defenses against overeating. The results may strengthen the case that consumers reduce sat fat content in their diets, and that producers reformulate food products with less saturated fat. Their findings were reported in The Journal of Clinical Investigation.
Christopher Kemp, Stephen Benoit et al, "Palmitic acid mediates hypothalamic insulin resistance by altering PKC-? subcellular localization in rodents", The Journal of Clinical Investigation, September 14, 2009, © American Society for Clinical Investigation
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