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Simple Way To Orally Deliver An Appetite-Suppressing Hormone In The Works

November 21, 2011: 12:00 AM EST
U.S. and Australian researchers believe they may soon have a simple way to get an appetite-suppressing hormone into the bloodstream easily – by chewing a vitamin B12 gum after meals. The hormone PYY is a component of a chemical system in the body that regulates appetite and energy. Eating and exercising releases PYY into the bloodstream. The researchers had already developed a way to attach insulin to vitamin B12 to deliver it safely through the digestive system. They have now been able to attach the PYY hormone to this patent-pending vitamin B12 delivery system. The next step is to find a way to insert the B12-PYY system into such things as chewing gum or oral tablets to create a nutritional supplement.
Christopher H. Fazen et al., "Oral Delivery of the Appetite Suppressing Peptide hPYY(3–36) through the Vitamin B12 Uptake Pathway", Journal of Medicinal Chemistry, November 21, 2011, © American Chemical Society
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