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Strawberry Flavonoid Reduces Complications From Diabetes

June 27, 2011: 05:51 PM EST
U.S. researchers have found that fisetin, a flavonoid that occurs abundantly in strawberries and in other fruits and vegetables, lessens complications of diabetes and could be used to treat other medical conditions. Earlier research has shown that fisetin promotes survival of neurons grown in culture and enhances memory in healthy mice. The new study demonstrates in a mouse model of type 1 diabetes that fisetin prevents both kidney and brain complications. Diabetic mice fed a fisetin-enriched diet remained diabetic, but acute kidney enlargement seen in untreated mice was reversed. High urine protein levels, a sign of kidney disease, also fell. Researchers said the therapeutic effect was associated with reduced levels of proteins known as advanced glycation end-products-or AGEs.
Pamela Maher, et al. , "Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes", PlosOne, June 27, 2011, © Maher, et al., Creative Commons Attribution License
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